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ALCAR and KET also activated brainstem nuclei (locus coeruleus, diagonal band, and raphe nuclei) which send aminergic projections to cortical areas and spinal dorsal horns that are involved in pain and mood control (Freo et al., 2010

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In nucleated cells, caspase-8, which is an initiator caspase of the extrinsic apoptotic pathway [144], has been identified as a molecular switch between apoptosis, necroptosis, and pyroptosis [145147]

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