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Despite significant progress observed in clinical trial development, there remains a scarcity of published clinical data, particularly regarding long-term safety, efficacy across diverse populations, and real-world effectiveness

Aaron Kesselheim, an expert on FDA law and professor at Harvard Medical School and Brigham and Women's Hospital

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These studies are not exhaustive and attempt to provide an overview of realistic scenarios of how novel formulations of supplements may impact their bioavailability

Fisher A, Pittel Z, Haring R, Bar-Ner N, Kliger-Spatz M, Natan N, Egozi I, Sonego H, Marcovitch I and Brandeis R (2003) Ml muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy

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