This is why its effects are so widespread, from improving skins appearance to supporting wound healing
It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability
These adaptations reflect neuroplastic remodeling of pain circuits rather than restoration of tissue integrity
doi: 10.7554/eLife.29985 195
Every individual has a change process due to the natural production of glutathione in the body, liver health, depletion due to aging, chronic stress, poor sleep, and environmental stresses
The increase in UA following uricase knockout resulted in attenuation of behavioural and neurochemical pathology, while animals overexpressing this gene showed an enhancement of these measures