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This depletion alters the cellular epigenetic landscape, which in turn dysregulates immune-modulatory pathways like the complement system

A clinical trial by Prez-Guisado & Jakeman, 2010 Journal of Strength and Conditioning Research demonstrated that individuals who supplemented with citrulline malate experienced significantly less soreness 2472 hours after training

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And the formula packs in a lot of high-achiever ingredients the 3-O-ethyl ascorbic acid derivative of vitamin C is rounded out with gently smoothing additions, such as niacinamide and lactic acid

doi: 10.1016/S1474-4422(13)70051-6 9