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Bottom line SURMOUNT-4 ended the course-of-treatment story

Genetic variants in GLP1R rs6923761 and GIPR rs1800437 don't predict your exact medication response, but they do suggest how efficiently your body's natural GLP-1 system functions

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This rapid clearance after injection means that sustained delivery methods may be necessary for meaningful bone healing effects

[9] To be able to confirm possible cardiovascular benefits of DPP-4 inhibitors requires large, double-blind, randomized trials with formal adjudication of cardiovascular end points