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Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

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These include proton pump inhibitors and histamine H 2 blockers, which suppress gastric acid secretion and prevent release of vitamin B 12 from food.42 Other drugs like metformin reduces intestinal availability of free calcium ions for vitamin B 12 intrinsic factor complex uptake by ileal cell membrane receptors,43 and cholestyramine interferes with vitamin B 12 absorption from intestine.44 Clinical manifestations of vitamin B 12 deficiency Vitamin B 12 is essential for metabolism of all cells in our body

DeBerardinis RJ, Chandel NS

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These reactions are usually transient and often decrease with continued administration