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Akkermansia muciniphila is a widely studied keystone species of the gut microbiome associated with intestinal mucus layer health, microbiome balance, and metabolic signaling

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" But that's not the way we should be using drugs, flying blind, coming up with our own solutions," he says

To gain insight into the potential structure of NAPstar, we used AlphaFold2 with the 919 amino acids of NAPstar3 as the input (Supplementary Information)

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(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)