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Conclusion# Retatrutide and survodutide both represent significant advances in multi-agonist metabolic therapy, but they take different approaches

Many patients report mood improvements on Ozempic, sometimes described as reduced anxiety around food, a quieting of obsessive thoughts about eating, and a general sense of improved wellbeing that they attribute partly to weight loss and partly to something more direct

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The reported incidence varies across specific agents and doses, with fatigue sometimes grouped with asthenia or malaise in adverse event reporting

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Previous studies have shown that the sustained loss of GABAergic interneurons induced by ketamine was linked to an upregulation of the enzyme responsible for the synthesis of superoxide radicals, which are responsible for stereotypical behaviors and depression (21, 85)