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In addition, GLP-1 activation in astrocytes by GLP-1R altered cellular glucose metabolism, revealing a novel mechanism by which GLP-1R improves cognitive function in patients with AD (Zheng et al., 2021)

The FDA recently approved another use for semaglutide, allowing it to help patients battling chronic weight management

This powerful tripeptide consists of three amino acids: glutamic acid , cysteine , and glycine

10.1111/jgh.13808 [DOI] [PubMed] [Google Scholar] 44.Tan Y, Guan Y, Sun Y, Zheng C

Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

Jeyaraman M, Muthu S, Sharma S, Ganta C, Ranjan R, Jha SK