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Experimental autoimmune encephalitis (EAE) is a well-established animal model that accurately mimics the CNS demyelinating lesions and T-cell responses observed in MS [260]

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September 2016;36(8):743-748), the authors discounted the accuracy of the LA/Ao measurement of LA size, stating: "In this study, the obtained results were not compared with the standard values from the tests considered to be 'gold standard' for LA volume measurement, such as MRI and CT

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Experimental animals were housed individually and had free access to drinking water