tirzepatide in hfpef Effectiveness of patients with using a target trial emulation retrospective cohort study Tirzepatide Benefits in Obesity-Related HFpEF

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Additionally, GLP-1R signaling in -cells activates mTOR-dependent transcription of hypoxia-inducible factor 1 alpha (HIF-1), which upregulates glucose expression and promotes glucose metabolism [8, 9]

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Concerns about suicidal ideation and other mental health effects emerged following post-marketing surveillance reports and patient anecdotes shared on social media platforms