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Simultaneously, glutathione (GSH), not only an indicator of oxidative stress, but also an important role in detoxification of the acetaminophen metabolite NAPQI, was determined to ascertain whether there was a difference in its depletion in the APAP-treated mice

1e): 3,9,14,15,30,34,46,57,60 (i) The thiolate of the reduced monothiol class I glutaredoxin directly attacks the disulfide substrate followed by the stepwise reduction of the mixed disulfide and Grx(SSG) by two molecules of GSH

It was discovered during research at the University of Zagreb, Croatia, and has been studied extensively in animal models for its tissue-protective and regenerative properties

International Orthopaedics

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