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The understanding of this mechanism was later derived from a separate study involving mice.

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According to the authors, boosting GSH status beneficially upregulates the genes of VD metabolism and VDR, both of which are needed to increase the bioavailability and blood levels of 25(OH)VD and reduce inflammation levels. They also found that co-supplementation with vitamin D and L-cysteine resulted in the upregulation of vitamin D regulatory genes and boosted vitamin D levels in the blood, as well as reduced inflammation and insulin resistance each with higher success compared to supplementing with vitamin D alone