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These are analogs of GLP-1 with longer half-lives and sustained action, effectively enhancing insulin secretion and inhibiting glucagon release

Is it the decreased inflammation from a significant weight loss

Retatrutides direct effect on skin is poorly defined

It stimulates insulin secretion, reduces hunger, and helps regulate blood sugar

Beyond that, degradation accelerates rapidly

Other considerations include if this class of medications is dropped from coverage, patients on the drugs will need to find other ways to pay for it if they want to continue, the affordability and availability of the medications, and what will the long-term impact be if patients stop taking the medications suddenly