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In the STEP trials, semaglutide was administered as part of a comprehensive lifestyle intervention that included a reduced-calorie diet (approximately 500 kcal/day deficit based on baseline energy requirements) and a minimum of 150 min of physical activity per week [38,39,40,41,42,43,44,45,46, 78, 97]

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L-carnitine inhibits both triiodothyronine (T3) and thyroxine (T4) entry into the cell

The SURMOUNT trials showed that non-diabetic participants on tirzepatide experienced no severe hypoglycemic events and minimal symptomatic low blood sugar