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[3] Methylene blue can cause sweating or a feeling of being warm, and occasionally your skin might take on a slight blueish tint if youre on a higher dose (this is usually harmless and fades)

And it influences the hypothalamic-pituitary-adrenal axis, which connects immune regulation to stress response, an important consideration given that psychological stress is a known trigger for lupus flares

Bhanote, M., Hicks, D.G., Pathology Case Reports: Pathology Case Reports, Elsevier Health Sciences

Can I use the same syringe for drawing water and for injecting my dose

And it's probably not that surprising if you really had significant change in your body weight and you now have metabolic regulation coming back in, it's going to conspire to regain your weight

Short-term irritation, if it occurs, doesn't negate long-term benefits