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These effects are therapeutically useful for diabetes and obesity management, but they may complicate fasting assumptions before anesthesia or deep sedation

reuteri enhancing GLP-1 production and for Akkermansia supporting gut barrier function during GLP-1 therapy

But as of today, Glucagon-Like peptide 1 receptor agonists (GLP1-RAs), sodium-glucose cotransporter 2 inhibitors (SGLT2is), dipeptidyl peptidase 4 inhibitors (DPP4is) and mineralocorticoid receptor antagonists, are quickly becoming part of, if not the drugs of choice for diabetes, especially in cases with heart, kidney or liver comorbidities [9,10,11,12]

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The decision is individual and clinical

At week 20, the change from baseline in HbA1c in patients treated with sitagliptin (N=95) was 0.06% compared to 0.23% in patients treated with placebo (N=95), a difference of -0.17% (95% CI: -0.62, 0.28)