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Berberine has secondary evidence for metabolic support

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WHO Decision Recognizing Obesity as a Disease Treatable with GLP-1 Drugs Is Big Deal, says BU Endocrinologist New guidelines will help reduce stigma around weight management, Ivania Rizo says WHO Decision Recognizing Obesity as a Disease Treatable with GLP-1 Drugs Is Big Deal, says BU Endocrinologist New guidelines will help reduce stigma around weight management, Ivania Rizo says The World Health Organizations new guidelines recognizing obesity as a disease and suggesting that GLP-1 drugs be part of long-term treatment could have wide-ranging benefits, says Ivania Rizo, a Boston University endocrinologist whose research interests center on obesity, diabetes, and metabolic disorders

However, the most favorable effects on bone mineral density and microarchitecture were noted at concentrations much higher than those approved for human obesity treatment

You have to look at your nutrition