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MTHFR is involves in the process that recycles homocysteine (a common amino acid in your blood)

Mukherjee, Journal of Physical Chemistry C 123, (2019) 2904729056

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Its clinical program in the 1990s in Croatia (intended for approval for Crohns disease, an autoimmune inflammatory bowel disease) stopped at Phase 2

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Animal care was in compliance with standard operating procedures (SOPs) of the Animal Pharmacology Facility and the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (ETS 123)