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These findings align with preclinical data showing that circadian disruption enhances TNBC tumor growth and impairs the time-dependent efficacy of cisplatin therapy, suggesting that both intact circadian signaling and melatonin rhythms are crucial for optimizing chemotherapeutic outcomes 58

Furthermore, this possible effect may be related to anti-inflammatory activity of SGLT2i [31,32]

Insulin resistance is a hallmark feature of PCOS, present in approximately 5070% of affected women (higher in those with obesity)

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One possible side effect that has gained attention is orthostatic hypotension

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