However, it never received FDA approval because the results, while positive, weren't dramatic enough to meet regulatory thresholds for an obesity drug
PMID: 36510640
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99% purity by HPLC and mass spectrometry is essential and C18 fatty acid hydrolysis products restoring the unconjugated peptide backbone, Aib8-to-Ala8 epimerisation products restoring DPP-IV sensitivity, linker hydrolysis fragments, and aggregated fatty acid conjugate species would show substantially altered GLP-1R binding kinetics, half-life pharmacokinetics, and downstream signalling profiles confounding quantitative receptor pharmacology and comparative biology studies
Article New pills and expanded indications are poised to alter the dynamics of GLP-1 costs and treatments
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