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In an allergic mouse model, GLP-1 levels were decreased in lung tissue and BALF following exposure to lipopolysaccharide (LPS) but were restored when treated with a GLP-1RA [75]

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When blood glucose levels return to normal, the incretin effect diminishes, maintaining blood glucose at normal levels with high safety (60, 61)

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Without that, clinicians look at the whole picture: indication, baseline health, diabetes status, cardiovascular risk, gastrointestinal history, pregnancy plans, other medications, and the ability to follow up safely