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10.1074/jbc.M212355200 37

Follow-up labs are recommended every 3 months during treatment

Regulations could tighten, restricting access, or relax, enabling broader legitimate use

Citrus Aurantium (Bitter Orange): Contains synephrine, a natural thermogenic compound frequently used to increase metabolic output and suppress persistent appetite

These gastrointestinal effects typically occur most prominently during dose initiation and escalation, and often diminish over time as the body adjusts to the medication