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The results are consistent with the findings of a prior Phase IIb trial in that there was a very large placebo effect and no treatment effect, Transzyme said in a December 17, 2012, statement following the end of the latter trial, which assessed once-daily dosing

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Endogenous GLP-1 has a short half-life (23 minutes) and is rapidly metabolised after its secretion via the enzyme dipeptidyl peptidase (DPP-4), while GLP-1RAs have a prolonged half-life of approximately 7 days [2, 3], resulting in some long-lasting effects

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