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By Route of Administration: Parenteral dominates, Oral growing fastest Parenteral (subcutaneous injection) delivery held the dominant route of administration position in 2025, reflecting that all high-dose, high-efficacy GLP-1 formulations currently approved for obesity management require injection for the delivery of drug quantities sufficient to achieve therapeutic plasma concentrations

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Lubiprostone (Amitiza) is a prostaglandin E1 analog that stimulates fluid secretion into the intestine by directly and selectively acting on the chloride receptor ClC-2

Bartziokas K, Papaioannou AI, Loukides S, et al

Emerging mitochondrial-mediated mechanisms involved in oligodendrocyte development