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Diarrhea May occur especially during dose adjustments

Acknowledgements The authors are greatly indebted to Arisa Kitagawa, Sanae Aratani, and Nanase Suyama for her continued support of our research efforts

Statistical Analysis The full analysis set (FAS) included all 43 subjects who were exposed to at least 1 dose of trial drug

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Metformin changes the way the body regulates blood sugar, and, as a result, it can decrease a person's appetite