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These varying observations highlight the critical distinction between enzyme concentration and actual catalytic activity, as evidenced in other inflammatory conditions where plasma SOD1 concentration increased while total activity remained unchanged (Sciskalska et al., 2020)

As an intracellular antioxidant, it is involved in cellular redox balance and various metabolic processes

Dorenkamp M, Mller JP, Shanmuganathan KS et al (2018) Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis

This can aggravate brain fog rather than relieve it

10.1128/MCB.01038-08

The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex