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One obvious advantage of the small molecule agonists in the replacement of peptide GLP-1 analogues is that they could be administered orally, thus avoiding the discomfort of subcutaneous injections and increasing the compliance of patients

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Ongoing trials are evaluating the optimal sequencing and combination of these agents to further improve outcomes (Fig

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Liver fat reduction: the retatrutide advantage One area where the dosage comparison reveals a dramatic difference is liver fat reduction