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Known as Sakel's technique, insulin coma therapy was a common treatment for schizophrenia until the late 1950s when it fell out of fashion (Marks 2018

For some people, microdosing GLP-1 medications may work for their health goals

This may be partly mediated by improvements in weight loss and glucose control

Neurology (1999) 53(9):193742

We now know that patients frequently discontinue GLP-1 therapy within months, negating long-term benefits, and also struggle to meet the requirements of lifestyle changes that are prescribed alongside the medication