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While their preclinical efficacy is promising, clinical translation has been limited by poor bioavailability
Its usually taken once or twice daily and is available as a low-cost generic as well as in several brand-name and combination products
Good balance of nutrition and convenience
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NNMT sits at high levels in fat tissue, in many cancer cells and in tissue under metabolic stress, where it acts as a metabolic sink: it consumes NAD+, the coenzyme that powers energy production and cell repair, and S-adenosylmethionine (SAM), the cells main methyl-group donor
Deng, C
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