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Most of these pathways are well understood at a mechanistic level
We have moved from simply stimulating a single pathway to orchestrating a symphony of hormonal signals
CR-fed females showed upregulation of pathways including Lysine degradation, and Valine, leucine, and isoleucine degradation. Interestingly, DL-fed females had no significantly upregulated pathways, and indeed CR-fed females had upregulation of Valine, leucine, and isoleucine biosynthesis, while DL-fed females had downregulation of this same pathway
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StAR protein and the regulation of steroid hormone biosynthesis
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