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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, WARNINGS]

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The mixture was diluted with deionized water (200 mL) and filtered

10.1038/leu.2017.171 Leukemia 108 MinorE

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