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Thyroid hormone receptor agonists mimic endogenous T3 signaling, promoting mitochondrial biogenesis across multiple tissues and raising basal metabolic rate to increase systemic energy consumption [43]

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Behavioral measurements should primarily include the percentage of time spent in the open quadrant, the percentage of entries into the open quadrant, the number of times the animal peeks down from the edge of the platform while in the open or closed quadrant, and the number of stretch-attend postures from the closed quadrant to the open quadrant