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A single injection dose contained 1 or 4 g of PV1 wtVLP or sVLP without adjuvant, or half a human dose of commercial IPV vaccine (20 DU for PV1, Sanofi Pasteur) in a final volume of 500 l, respectively

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This is corroborated by setmelanotides clinical trials, where participants with monogenic obesity or HO respond more strongly to treatment than general obese participants (NCT02041195, NCT01749137) (87, 9094)

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Currently, there are no effective treatments for SIM, with a focus on prevention, commonly involving blood glucose control, early anti-inflammation treatment, early enteral nutrition, and early exercise and rehabilitation (13)