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Bariatric surgery referral may be considered for eligible patients with BMI 40 kg/m or BMI 35 kg/m with obesity-related complications who experience significant weight regain after medication discontinuation

Again, thats unprecedented in medical history

176,210,211 These effects involve interactions with other satiety and hunger signals, such as PYY, CCK, insulin, and leptin

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GLP-1 medications are peptide-based compounds with relatively high molecular weight and low lipid solubility

Rather than being broken down quickly, it feeds beneficial gut bacteria, which then produce compounds that encourage GLP-1 release