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Preclinical studies have demonstrated that GLP-1 RAs attenuate alcohol intake and reduce the ethanol-induced activation of mesolimbic dopaminergic pathways, highlighting their ability to modulate dysregulated reward circuitry associated with AUD [6,21]
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Similarly, the activation status of Gq signaling was probed following GPR146 knockdown by performing an IP1 assay using the IP-One Gq Kit (PerkinElmer)
This reinforces the overall effectiveness of GLP-1 medications in promoting weight loss
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