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NLRP3 inhibitor Oridonin can suppress the expression of IL-18 and IL-1, alleviate inflammation, preserve myocardial function and improve myocardial remodeling by reducing NLRP3 expression [89]

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Diabetes Obes Metab (2014) 16(9):85060

Evidence for Kidney Benefits Clinical trials show consistent kidney benefits: FLOW trial (semaglutide): This dedicated kidney outcome trial showed semaglutide reduced the risk of major kidney outcomes (kidney failure, significant decline in kidney function, or kidney-related death) by 24% in diabetic patients with chronic kidney disease

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