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These results point to an exquisitely tuned receptor able to differentiate between subtle differences in ligand structure to produce varied intracellular responses

TRPV1 is expressed in about 60% of vagal neurons, and TRPA1 in about 25%.[ref] In addition to chemical stimuli, TRP receptors respond to oxidative stress and systemic inflammation.[ref] Repeated activation and hyperexcitability: TRPA1 and TRPV1 receptors are often co-localized on the same cells

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The good news is research into this approach continues

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And with that, in this particular patient, her lymphedema went from mild to not so mild anymore