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28 , e937766 (2022)
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Mechanistically, the accumulation of serotonin due to MAO-A blockade by MB can overstimulate serotonin receptors, resulting in agitation, hyperthermia, tremor, and other symptoms of serotonin toxicity
Meanwhile, mTORC1, in nutrient-rich conditions, activates forkhead box K1/2 (FoxK1/2) which counters Foxo3-induced activation of autophagy by restricting the acetylation of histone H4 and expression of critical autophagy genes [299]