PLoS Pathog
Ekinci: Has been a member of advisory boards for Eli Lilly, Sanofi, Pfizer, and Bayer
Generic orforglipron, when it eventually becomes available, could see pricing discounts of 80-90% below brand, following the pattern seen with other generic small molecules
If the anatomy restricts ensured removal, medical oncologists and radiation oncologists must provide the most appropriate adjunctive therapy
The small sample sizes ( n = 169 for T2D and n = 254 for obesity) compared to clinical trials, as well as a lack of representativeness in the study population relative to national prevalence rates, further undermine generalizability
Commercially, interchangeable biosimilars can be substituted at the pharmacy level in states that permit automatic substitution, without requiring an explicit prescriber switch