Data processing was carried out using the AutoPROC (Vonrhein et al., 2011) toolbox (Global Phasing) executing XDS (Kabsch, 2010), Pointless (Evans, 2006), and Aimless (Evans and Murshudov, 2013)
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Both open (Protein Data Bank (PDB) 3KAK) and closed (PDB 3KAL) active site forms of hGSH synthetases have been crystallized, with the phosphorylation and amide bond-forming steps proposed to be catalyzed in the closed form 52
N-Acetyl Cysteine (NAC) in the treatment of obsessive-compulsive disorder: A 16-week, double-blind, randomised, placebo-controlled study