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doi: 10.1073/pnas.1918314117

Notably, in the latter study, many of the arrestinbiased agonists in fact showed reduced efficacy for arrestin recruitment, but high potency

"Competition is very healthy, as long as it's legal

[American Journal of Physiology] Laskowska M, Oleszczuk J

Starting both medications simultaneously makes it impossible to identify which medication is causing which side effects, makes dose titration dangerous because you cannot isolate responses, and maximizes the risk of overlapping side effects like nausea

Discussion Overall, participants with obesity and/or T2D described a positive impact of GLP-1 receptor agonists on their mental health, especially perception of improved control of eating behaviours