Oxid Med Cell Longev 2019 , 1704650
The C-terminal of PLC- isoforms shows some differences, and the PLC- subfamily has a unique 450-amino acid long C-terminal extension, but the significance of this difference is unknown
Benua RS, Kumaoka S, Leeper RD, Rawson RW
Discovered in 2015 by Changhan David Lee and Pinchas Cohen at USC, MOTS-c is encoded in the 12S rRNA region of the mitochondrial genomemaking it one of a small but growing family of mitochondrial-derived peptides (MDPs) that challenge the longstanding view of mitochondria as passive energy factories.1 This discovery sheds new light on mitochondria and positions them as active regulators of metabolism. Changhan David Lee, Assistant Professor of Gerontology, USC Leonard Davis School12 The Exercise Connection Human studies show that circulating endogenous MOTS-c levels increase approximately 1.6-fold during exercise and remain elevated about 1.5-fold post-exercise before returning to baseline after roughly four hours.13 This temporal profile suggests MOTS-c functions as an exercise-induced mitokinea signaling molecule released by mitochondria in working muscles that communicates metabolic status to the rest of the body
Semaglutide acts on the pancreas to reduce both pre- and post-prandial blood glucose concentrations in a glucose-dependent manner primarily by increasing insulin production and inhibiting the secretion of glucagon
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