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In addition to its activity against hyperglycemia, DPP-4i has shown beneficial cardiovascular effects including cardioprotective action, endothelial protection, and an anti-hypertensive effect

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Because of these properties, pumpkin is commonly included in dog food formulations to support digestive wellbeing and overall vitality

Its obesity data come from a Phase 2 randomized trial published in the New England Journal of Medicine in 2023 by Jastreboff and colleagues, which enrolled 338 adults with obesity over 48 weeks

J Soc Nutr Food Sci 4:2731

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