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Moxit Shah
First principles for therapy design Therapy design should follow three first principles: target the source before the sink, prioritizing isoform- or site-specific modulation of NOX enzymes, mitochondrial ROS sites, ER oxidoreductases, or iron handling rather than indiscriminate scavenging that can blunt physiological signalling (Sies et al
In the REWIND study, DR was defined as photocoagulation, anti-vascular endothelial growth factor therapy, or vitrectomy [8], whereas DR was determined when patients had vitreous hemorrhage, the onset of diabetes-related blindness, and the need for treatment with an intravitreal agent or retinal photocoagulation in the SUSTAIN-6 [9] and LEADER trials [10]
Complete resolution of symptoms after one treatment was reported in 10 out of 12 patients, who rated their success at 100%
while in contrast, the combination of pyridoxine with amlodipine resulted in a trend towards increased adverse cardiovascular events
Nature 372:425432 Heymsfield SB, Greenberg AS, Fujioka K et al (1999) Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial
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