MAT2A inhibition blocks the growth of MTAP-deleted Cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
The following mutants were generated: for p97-ND1LP246T, P247A, P247K, K251A, D304N, E305Q, K312A, K312E, K312R, K312R-R313A, R313A, R313A-E314R, K315A, N348Q, R349A, R359A, R359A-R362A, R359K, F360A, Cys-F360C-A413C (Cys: C69V-C77V-C105A-C174A-C184W-C209V-C415A), F360P and R362A
Food sources of vitamins C and E: Vitamin C: oranges, grapefruit, clementines, red and green bell peppers, kiwi, tomatoes, broccoli, potatoes, strawberries, cantaloupe, passion fruit, guava, goji berries, durian and mango Vitamin E: olives, olive oil, avocados, avocado oil, peanuts, seeds, nuts, spinach, broccoli, sunflower oil and safflower oil Green tea and curcumin EGCG (a catechin found in green tea) and curcumin (found in the spice turmeric) have both been shown to reduce inflammation in the body
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Chem ., 1989, no
Trends Neurosci 2004;27:3707