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P-values for efficacy estimand are nominal The treatment-regimen estimand is the estimated treatment effect, regardless of whether the patient adheres to the treatment, discontinues, or initiates other therapies References 1 Boehringer Ingelheim

(12(3)):368-371 doi:10.1007/s12519-016-0042-x

Imbalance in redox states generates the reactive oxygen species (ROS) which causes several deleterious effects in the living cells

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