The paper noted: Insulin resistance at the level of the retina is also postulated to play an important role in the pathophysiology of nAMD, which may be more pronounced in the neovascular form of the disorder
Bioinformatic analyses of synaptic transmission in spiral ganglion neurons have highlighted NGF and its interaction with NTRK1 (TrkA) and NGFR (p75NTR) as potentially relevant to the tinnitus process, suggesting that the NGF-signaling pathway may be of comparable importance to BDNF signaling in tinnitus networks although this awaits functional validation (Gross et al., 2023)
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The researchers note that since weight loss is observable to participants, this could have led to informative censoring and participant action to discontinue or switch medications
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