So far, the reports of liver problems like jaundice (yellowing of the eyes or skin) are very rare
Moreover, GLP-1RAs may affect tumor initiation and progression by modulating microRNA expression patterns and influencing epigenetic modifications
In rat HD models, neuropathological changes in the rat striatum were induced by 3-nitropropionic acid, and L-theanine exhibited neuroprotective effects, which mainly depended on not only inhibiting the production of harmful NO but also preventing the change of neurotransmitters in the striatum (51)
They just started May 30th with just starting the Phase three trials
In the SURMOUNT-1 trial, adults with obesity or overweight taking tirzepatide lost an average of 15 to 22% of their body weight over 72 weeks, depending on the dose
That sounds like a win, but in high quantities, sugar alcohols can worsen the GI side effects you're already trying to avoid