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Reactions were assessed at 24 and 72 hours after application

J Pediatr 159:10041011

LDN: The universal principle is start low, go slow. A typical ldn titration starts at 0.5 mg or 1.5 mg taken at bedtime, increasing by 1.5 mg every 2-4 weeks until a target dose of 4.5 mg is reached, or until positive effects are noted at a lower dose